PHAR 9926 Changes in PK parameters of drugs

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Normal values for the pharmacokinetic parameters: clearance, fraction unbound in plasma, and fraction excreted unchanged are listed in Table below for Drugs A through G. Situations are presented that alter the kinetics of each of these drugs. On the right, indicate whether the value of each parameter would be observed to in-crease (↑), decrease (↓), or show little or no change (↔) and justify your answers. Each drug is administered orally and has a volume of distribution greater than 50 L